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Caroli Sergio Analytical Techniques for Clinical Chemistry. Methods and Applications


Discover how analytical chemistry supports the latest clinical research This book details the role played by analytical chemistry in fostering clinical research. Readers will discover how a broad range of analytical techniques support all phases of clinical research, from early stages to the implementation of practical applications. Moreover, the contributing authors' careful step-by-step guidance enables readers to better understand standardized techniques and steer clear of everyday problems that can arise in the lab. Analytical Techniques for Clinical Chemistry opens with an overview of the legal and regulatory framework governing clinical lab analysis. Next, it details the latest progress in instrumentation and applications in such fields as biomonitoring, diagnostics, food quality, biomarkers, pharmaceuticals, and forensics. Comprised of twenty-five chapters divided into three sections exploring Fundamentals, Selected Applications, and Future Trends, the book covers such critical topics as: Uncertainty in clinical chemistry measurements Metal toxicology in clinical, forensic, and chemical pathology Role of analytical chemistry in the safety of drug therapy Atomic spectrometric techniques for the analysis of clinical samples Biosensors for drug analysis Use of X-ray techniques in medical research Each chapter is written by one or more leading pioneers and experts in analytical chemistry. Contributions are based on a thorough review and analysis of the current literature as well as the authors' own firsthand experiences in the lab. References at the end of each chapter serve as a gateway to the literature, enabling readers to explore individual topics in greater depth. Presenting the latest achievements and challenges in the field, Analytical Techniques for Clinical Chemistry sets the foundation for future advances in laboratory research techniques.

19272.73 RUR

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Группа авторов Manual of Clinical Procedures in the Horse


Manual of Clinical Procedures in the Horse is a detailed step-by-step guide to clinical skills in equine practice. With information on techniques ranging from physical examination and blood sampling to lameness and neurologic exams and other specialized procedures, the book is an aid to confidently and effectively performing procedures used in daily equine practice. Well illustrated with clinical photographs throughout, the book’s focus is on providing thorough, easy-to-understand descriptions of 80 techniques necessary for examining and treating horses. Each topic includes a summary of the purpose, potential complications, equipment and proper restraint for each procedure, with a detailed description of each action for the technique and the rationale behind it. More than 1,100 full-colour clinical photographs demonstrate the techniques. Manual of Clinical Procedures in the Horse is an essential purchase for any veterinary practice seeing equine patients. Key features Details each step for 80 common procedures for veterinary care of the horse Supports veterinarians and technicians in performing techniques in daily equine practice Presents more than 1,100 images depicting the steps described in the text Covers the purpose, potential complications, equipment, restraint, actions and rationale for each procedure Offers a practical patient-side reference to essential techniques in clinical practice, ranging from basic assessment to specialized procedures

10668.07 RUR

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Группа авторов Clinical Diabetes Research: Methods and Techniques


A practical «how to» guide for multiple methods in metabolism, with a critical and objective discussion of strengths, limitations, and appropriate applications of the described methods. Edited by the winner of the Oskar-Minkowski Prize of the EASD in 2006 Clinical trials in populations at risk of or with overt diabetes mellitus are being performed all around the world to test novel drugs and approaches to managing these diseases. During the last decade, new methods and techniques have been introduced – and are being developed further – that facilitate monitoring of metabolism and even diagnosis of certain defects in human metabolism. While some of these methods are restricted to research facilities, others are already used in clinical practice. The correct beneficial use of these methods requires knowledge of the nature of the techniques and their clinical relevance. Clinical Diabetes Research: Methods and Techniques provides summaries of established state-of-the art-techniques and introduces the new technologies, evaluating their potential in clinical diabetes research. One section compares the efficacy of all metabolic tests that measure insulin action. Another section describes methods that allow quantification of whole body and intracellular metabolic fluxes relevant to diabetes research. The final section focuses on the planning and pitfalls of clinical studies in the field of metabolism. Each chapter throughout the book combines the theoretical basis of the approach with practical recommendations. There are further chapters on the design of clinical trials and ethical considerations. The publication is timely in view of the impressive development of the methods and techniques with their application to understanding the pathophysiology of diabetes, insulin resistance syndromes, obesity, and the metabolic effects of treatment. Clinical Diabetes Research: Methods and Techniques is of great relevance for researchers (from students and post-docs to principal investigators) in the field of human metabolism, clinical endocrinologists and diabetologists who are involved in clinical studies.

20636.37 RUR

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Richard Cousley The Orthodontic Mini-implant Clinical Handbook


Offers the very latest on the theory and practice of integrating mini-implant techniques into clinical practice This all-new second edition of The Orthodontic Mini-implant Clinical Handbook provides a thoroughly revised and expanded update to the theoretical and practical aspects of using mini-implants in orthodontic practice. Taking a practical step-by-step approach with hundreds of clinical images, it presents updated clinical techniques and new clinical cases, covering all topics of importance for utilising mini-implants. It also includes a new chapter on mini-implant anchored maxillary expansion appliances. It begins with a chapter that looks at mini-implant principles and potential complications, before moving onto clinical and design factors for maximising mini-implant success. Other chapters cover incisor retraction; molar distalisation and protraction; intrusion and anterior openbite treatments; bone anchored rapid maxillary expansion; orthognathic surgical uses; and ectopic teeth. Provides a comprehensive guide to both theoretical and practical advice for the use of mini-implants in orthodontic practice Covers updated clinical techniques and new clinical cases Presents a new chapter on mini-implant anchored maxillary expansion appliances Takes a highly illustrated step-by-step approach ideal for clinical practice The Orthodontic Mini-Implant Clinical Handbook is an essential resource to orthodontists, maxillofacial surgeons, practicing dentists, and anyone with an interest in mini-implant skeletal anchorage.

12103.33 RUR

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Daniele Martini De Success Probability Estimation with Applications to Clinical Trials


Provides an introduction to the various statistical techniques involved in medical research and drug development with a focus on estimating the success probability of an experiment Success Probability Estimation with Applications to Clinical Trials details the use of success probability estimation in both the planning and analyzing of clinical trials and in widely used statistical tests. Devoted to both statisticians and non-statisticians who are involved in clinical trials, Part I of the book presents new concepts related to success probability estimation and their usefulness in clinical trials, and each section begins with a non-technical explanation of the presented concepts. Part II delves deeper into the techniques for success probability estimation and features applications to both reproducibility probability estimation and conservative sample size estimation. Success Probability Estimation with Applications to Clinical Trials: • Addresses the theoretical and practical aspects of the topic and introduces new and promising techniques in the statistical and pharmaceutical industries Features practical solutions for problems that are often encountered in clinical trials Includes success probability estimation for widely used statistical tests, such as parametric and nonparametric models Focuses on experimental planning, specifically the sample size of clinical trials using phase II results and data for planning phase III trials Introduces statistical concepts related to success probability estimation and their usefulness in clinical trials Success Probability Estimation with Applications to Clinical Trials is an ideal reference for statisticians and biostatisticians in the pharmaceutical industry as well as researchers and practitioners in medical centers who are actively involved in health policy, clinical research, and the design and evaluation of clinical trials.

8727.28 RUR

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Raquel Walton M. Equine Clinical Pathology


Equine Clinical Pathology is the first complete resource for hematology and clinical chemistry in horses. Encompassing the basic principles and advanced interpretation, the book’s single-species approach to pathology allows for focused coverage of the unique disease characteristics of equids. Equine Clinical Pathology is equally useful for anyone using clinical pathology as a diagnostic tool, from beginning student to experienced specialist. The heart of the book is organized by body system, making it easy to find and apply information. Chapters cover general laboratory medicine, including instruments and techniques, hematology, and proteins as well as specific organs, such as the kidney and liver. Equine Clinical Pathology is a useful bench-side reference for anyone involved in laboratory medicine for the horse.

12090.16 RUR

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Sonick Michael Implant Site Development


With the desire for dental implant therapy ever escalating, clinicians are faced with the challenge of augmenting deficient natural physiology to provide effective sites for implantation. Implant Site Development helps the clinician decide if, when, and how to create a ridge site amenable to implantation. This practical book offers solutions to many implant site preservation scenarios, discussing different treatment options, timing, a variety of materials and techniques, and their application to the clinical practice. With a unique integrated clinical approach, Implant Site Development covers a range of site development techniques. Highly illustrated, Implant Site Development presents diagrams and clinical photographs to aid with clinical judgment and will prove useful for any dental professional involved in implant therapy, from general practitioners to prosthodontists, but especially surgeons. This literature-based, yet user-friendly, reference will be indispensable to the novice or veteran clinician.

18726.52 RUR

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Michael Carroll Clinical Reproductive Science


The comprehensive and authoritative guide to clinical reproductive science The field of clinical reproductive science continues to evolve; this important resource offers the basics of reproductive biology as well as the most recent advance in clinical embryology. The author – a noted expert in the field – focuses on the discipline and covers all aspects of this field. The text explores causes of male and female infertility and includes information on patient consultation and assessment, gamete retrieval and preparation, embryo culture, embryo transfer and cryopreservation. Comprehensive in scope, the text contains an introduction to the field of clinical reproductive science and a review of assisted reproductive technology. The author includes information on a wide range of topics such as gonadal development, the regulation of meiotic cell cycle, the biology of sperm and spermatogenesis, in vitro culture, embryo transfer techniques, fundamentals of fertilisation, oocyte activation and much more. This important resource: Offers an accessible guide to the most current research and techniques to the science of clinical reproduction Covers the fundamental elements of reproductive science Includes information on male and the female reproductive basics – everything from sexual differentiation to foetal development and parturition Explores the long-term health of children conceived through IVF Contains the newest developments in assisted reproductive technology Clinical Reproductive Science is a valuable reference written for professionals in academia, research and clinical professionals working in the field of reproductive science, clinical embryology and reproductive medicine.

7196.97 RUR

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Gerard Meijer Smart Sensor Systems


With contributions from an internationally-renowned group of experts, this book uses a multidisciplinary approach to review recent developments in the field of smart sensor systems, providing complete coverage of all important system and design aspects, their building blocks and methods of signal processing. It examines topics over the whole range of sensor technology from the theory and constraints of basic elements, the applied techniques and electronic, up to the level of application-orientated issues. Developed as a complementary volume to ‘Smart Sensor Systems’ (Wiley 2008), which introduces the theoretical foundations, this volume focuses on practical applications, including: State-of-the-art techniques for designing smart sensors and smart sensor systems, with measurement techniques at system level, such as collaboration and trimming, and impedance-measurement techniques. Sensing elements and sensor systems for the measurement of mechanical quantities, and microarrays for DNA detection. Circuitdesign for sensor systems, such as the design of low-noise amplifiers, and measurement techniques at device level, such as dynamic offset cancellation and optical imagers. Implantable smart sensors for bio-medical applications and automotive sensors. A supplementary website hosts case studies and a solutions manual to the problems Smart Sensor Systems: Emerging Technologies and Applications will greatly benefit final year undergraduate and postgraduate students in the areas of electrical, mechanical and chemical engineering, and physics. Professional engineers and researchers in the microelectronics industry, including microsystem developers, will also find this a thorough and useful volume.

11181.82 RUR

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Jane Sturgess Applied Anatomy for Clinical Procedures at a Glance


Applied Anatomy for Clinical Procedures at a Glance is a concise resource combining high-quality images and step-by-step instructions to provide expert guidance on the major core training pathways in medicine, surgery and anaesthesia. Written by an experienced team of Foundation Training programme directors and clinical skills examiners, this unique revision and learning guide aligns with training pathways rather than anatomical area to support Foundation doctors and core trainees master these vital clinical procedures. Succinct yet thorough descriptions of each procedure include photographs of surface anatomy, line diagrams of the anatomy, instructions on the procedural techniques, and practical tips for performing the procedures safely whilst minimising risks of complications. All major aspects of Foundation procedures and Core training in applied anatomy are covered, including catheterisation, ECGs, central venous cannulation, basic suturing and anastomotic techniques, endotracheal intubation, epidural injection and spinal injection, defibrillation, and many others. Helps Foundation doctors and Core trainees apply their medical school knowledge in clinical settings Explains the common anatomical pitfalls of invasive clinical procedures Features practice questions on anatomy and clinical aspects to aid in preparing for clinical skills examinations Includes sections on aftercare and on specific equipment, including manometers and underwater seals Applied Anatomy for Clinical Procedures at a Glance is ideal for Foundation doctors and Core trainees, as well as medical students, physician’s assistants and surgical scrub practitioners.

3513.18 RUR

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Ekins Sean The Agile Approach to Adaptive Research. Optimizing Efficiency in Clinical Development


Apply adaptive research to improve results in drug development The pharmaceutical industry today faces a deepening crisis: inefficiency in its core business, the development of new drugs. The Agile Approach to Adaptive Research offers a solution. It outlines how adaptive research, using already-available tools and techniques, can enable the industry to streamline clinical trials and reach decision points faster and more efficiently. With a wealth of real-world cases and examples, author Michael Rosenberg gives readers a practical overview of drug development, the problems inherent in current practices, and the advantages of adaptive research technology and methods. He explains the concepts, principles, and specific techniques of adaptive research, and demonstrates why it is an essential evolutionary step toward improving drug research and development. Chapters explore such subjects as: The adaptive concept Design and operational adaptations Sample-size reestimation Agile clinical development Safety and dose finding Statistics in adaptive research, including frequentist and Bayesian approaches Data management technologies The future of clinical development By combining centuries-old intellectual foundations, recent technological advances, and modern management techniques, adaptive research preserves the integrity and validity of clinical research but dramatically improves efficiency.

8813.64 RUR

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Группа авторов The Neuroscience of Visual Hallucinations


Each year, some two million people in the United Kingdom experience visual hallucinations. Infrequent, fleeting visual hallucinations, often around sleep, are a usual feature of life. In contrast, consistent, frequent, persistent hallucinations during waking are strongly associated with clinical disorders; in particular delirium, eye disease, psychosis, and dementia. Research interest in these disorders has driven a rapid expansion in investigatory techniques, new evidence, and explanatory models. In parallel, a move to generative models of normal visual function has resolved the theoretical tension between veridical and hallucinatory perceptions. From initial fragmented areas of investigation, the field has become increasingly coherent over the last decade. Controversies and gaps remain, but for the first time the shapes of possible unifying models are becoming clear, along with the techniques for testing these. This book provides a comprehensive survey of the neuroscience of visual hallucinations and the clinical techniques for testing these. It brings together the very latest evidence from cognitive neuropsychology, neuroimaging, neuropathology, and neuropharmacology, placing this within current models of visual perception. Leading researchers from a range of clinical and basic science areas describe visual hallucinations in their historical and scientific context, combining introductory information with up-to-date discoveries. They discuss results from the main investigatory techniques applied in a range of clinical disorders. The final section outlines future research directions investigating the potential for new understandings of veridical and hallucinatory perceptions, and for treatments of problematic hallucinations. Fully comprehensive, this is an essential reference for clinicians in the fields of the psychology and psychiatry of hallucinations, as well as for researchers in departments, research institutes and libraries. It has strong foundations in neuroscience, cognitive science, optometry, psychiatry, psychology, clinical medicine, and philosophy. With its lucid explanation and many illustrations, it is a clear resource for educators and advanced undergraduate and graduate students.

15734.33 RUR

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Vera Mihajlovic-Madzarevic Clinical Trials Audit Preparation. A Guide for Good Clinical Practice (GCP) Inspections


A must-have guide for any professional in the drug manufacturing industry The Good Clinical Practice (GCP) audit is a tedious but necessary exercise that assures that all parties do their job properly and in compliance with the applicable FDA code. Clinical Trials Audit Preparation demystifies the audit process for all parties involved, including clinical research sponsors, clinical investigators, and institutional review boards. This book provides a step-by-step explanation of the FDA audit procedures for clinical trials and of how pharmaceutical companies, clinical investigators, and institutional review boards should prepare for regulatory audits. The book emphasizes the processes and procedures that should be implemented before a clinical audit occurs, making this an imperative guide to any professional in the drug manufacturing industry, including drug manufacturing companies, regulatory affairs personnel, clinical investigators, and quality assurance professionals. Among the topics discussed: Good Clinical Practices and therapeutic product development in clinical research The roles of the sponsor of a clinical investigation, the IRB, or independent ethics committee The roles and responsibilities of the clinical trial investigator The inspection preparation The Audit Report and the Form 483 Warning letters issued to clinical investigators and clinical trial sponsors and their impact on product development

9995.46 RUR

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Joseph R. Dettori SMART Approach to Spine Clinical Research


The <em>SMART Approach to Spine Clinical Research</em> is a must-have guide for spine care professionals seeking to make a meaningful contribution to the scientific literature and advance their careers by publishing high-quality clinical research.
Planning, conducting, and publishing the results of your clinical research can be a long and arduous journey. The <em>SMART Approach to Spine Clinical Research</em> presents and explains the many interrelated components essential to spine clinical research in an easily accessible way, guiding you step-by-step through the principles and methods of planning and evaluating clinical research.
Also addressed are special topics such as getting your manuscript published and conducting a meta-analysis. This SMART approach provides a clear and simple road map for the planning, execution, and critical appraisal of clinical research.

7953.79 RUR

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Antoni Bayés de Luna Clinical Arrhythmology


The study and management of abnormal heart rhythms is the core of Electrophysiology, but the successful identification and management of arrhythmias is important to a much wider range of physicians, from trainees in cardiology to general clinical cardiologists to practitioners in other areas of specialization, for example internists. This book is a thorough overview of clinical arrhythmology designed to help general clinical cardiologists and trainees in the fields of clinical cardiology and electrophysiology achieve the competency they need for clinical practice or for further specialization in the topics covered within the book.

15995.46 RUR

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Группа авторов Analysis of Clinical Trials Using SAS


Analysis of Clinical Trials Using SAS®: A Practical Guide, Second Edition bridges the gap between modern statistical methodology and real-world clinical trial applications. Tutorial material and step-by-step instructions illustrated with examples from actual trials serve to define relevant statistical approaches, describe their clinical trial applications, and implement the approaches rapidly and efficiently using the power of SAS. Topics reflect the International Conference on Harmonization (ICH) guidelines for the pharmaceutical industry and address important statistical problems encountered in clinical trials. Commonly used methods are covered, including dose-escalation and dose-finding methods that are applied in Phase I and Phase II clinical trials, as well as important trial designs and analysis strategies that are employed in Phase II and Phase III clinical trials, such as multiplicity adjustment, data monitoring, and methods for handling incomplete data. This book also features recommendations from clinical trial experts and a discussion of relevant regulatory guidelines.
This new edition includes more examples and case studies, new approaches for addressing statistical problems, and the following new technological updates:


SAS procedures used in group sequential trials (PROC SEQDESIGN and PROC SEQTEST)
SAS procedures used in repeated measures analysis (PROC GLIMMIX and PROC GEE)
macros for implementing a broad range of randomization-based methods in clinical trials, performing complex multiplicity adjustments, and investigating the design and analysis of early phase trials (Phase I dose-escalation trials and Phase II dose-finding trials)


Clinical statisticians, research scientists, and graduate students in biostatistics will greatly benefit from the decades of clinical research experience and the ready-to-use SAS macros compiled in this book.

5075 RUR

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Группа авторов Point-of-Care Ultrasound Techniques for the Small Animal Practitioner


This book offers a thorough revision and update to the first landmark book that presented a standardized approach to focused point-of-care ultrasound exams of the abdomen, thorax, musculoskeletal and eye in veterinary practice. Now incorporating new applications for focused ultrasound exams and additional species, this Second Edition continues to be a state-of-the-art reference for using abbreviated ultrasound exams in clinical practice. A companion website features supplementary video clips of these point-of-care techniques depicting actual ultrasound exams for comparison and comprehension.  New chapters in Point-of-Care Ultrasound Techniques for the Small Animal Practitioner, Second Edition cover ultrasound-guided nerve blocks, musculoskeletal, brain imaging, and applications of focused ultrasound techniques in cats, exotics and marine mammals—making it an essential purchase for veterinarians wanting to incorporate point-of-care ultrasound techniques into their veterinary practices.  Presents a standardized approach to point-of-care ultrasound as an extension of the physical exam, including trauma, non-trauma, and monitoring applications Includes coverage of new techniques for focused ultrasound exams, including lung, anesthesia and ultrasound guided nerve blocks, transcranial brain imaging, musculoskeletal, volume status evaluation, and rapid assessment for treatable forms of shock Adds cats, exotic and wildlife mammals, and marine mammals to the existing canine coverage Emphasizes the integration of point-of-care ultrasound techniques for optimizing patient care and accurate patient assessment Offers access to a companion website with supplementary video clips showing many clinically relevant didactic examples The second edition of Point-of-Care Ultrasound Techniques for the Small Animal Practitioner is an excellent resource for veterinary practitioners, ranging from the general practitioner to nearly all clinical specialists, including internal medicine, oncology, cardiology, emergency and critical care, anesthesiology, ophthalmology, exotics, and zoo medicine specialists, and veterinary students.

16484.09 RUR

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Rosalind Eeles A. Cancer Prevention and Screening. Concepts, Principles and Controversies


Cancer Prevention and Screening offers physicians and all clinical healthcare professionals a comprehensive, useful source of the latest information on cancer screening and prevention with both a global and a multidisciplinary perspective. Includes background information on epidemiology, cancer prevention, and cancer screening, for quick reference Offers the latest information for clinical application of the most recent techniques in prevention and screening of all major and many lesser cancer types Emphasises the importance of multidisciplinary teamwork in cancer screening Highlights frequent dilemmas and difficulties encountered during cancer screening Provides clear-cut clinical strategies for optimal patient education, communication, and compliance with cancer prevention techniques

11359.09 RUR

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Jenny Broersen Mindfulness and Schema Therapy


Mindfulness and Schema Therapy presents an eight-session + two follow up sessions protocol for schema mindfulness for therapists and their patients. Represents the first book to integrate the theory of schema therapy with the techniques of mindfulness Enhances schema therapy with techniques drawn from mindfulness-based cognitive therapy (MBCT) – a unique integration of two of the most popular treatment approaches in clinical psychology today. Merges two of the hottest topics in contemporary clinical psychology and psychotherapy Offers a practical guide for training and practice, with detailed coverage of theory followed by dedicated sections for therapists and patients Features a variety of exercises enabling readers to immediately implement the protocol Written by authors with expertise and experience in both schema therapy and mindfulness Includes a Foreword by Mark Williams, renowned for his contribution to the development of MBCT

8997.17 RUR

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Salah Abdel-aleem M. Design, Execution, and Management of Medical Device Clinical Trials


An essential introduction to conducting the various stages of medical device clinical trials Clinical research continues to be one of the most vital components of pharmaceutical, biostatistical, and medical studies. Design, Execution, and Management of Medical Device Clinical Trials provides a uniform methodology for conducting and managing clinical trials. Written in a style that is accessible to readers from diverse educational and professional backgrounds, this book provides an in-depth and broad overview for successfully performing clinical tasks and activities. Throughout the book, practical examples compiled from both the author's and other researchers' previous clinical trial experiences are discussed in a sequential manner as they occur in the study, starting from the development of the clinical protocol and the selection of clinical sites and ending with the completion of the final clinical study report. Next, readers are guided through the development of important clinical documents, including informed consent forms, case report forms, and study logs. A careful review of the Food and Drug Administration (FDA) and International Conference on Harmonisation (ICH) regulations applicable to medical devices is also featured. Additional coverage includes: Qualification and selection of investigators Study monitoring visits Definitions and reporting procedures for adverse events The use of biostatistical methodology in clinical research, including the use of biostatistics for sample size determination and study endpoints The roles and responsibilities of all members of a clinical research team The book concludes with an insightful discussion of special ethical conduct for human research and challenging issues to consider during the design of clinical studies. A glossary lists important clinical and statistical terms used in clinical research, and an extensive reference section provides additional resources for the most up-to-date literature on the topic. Design, Execution, and Management of Medical Device Clinical Trials is an excellent book for clinical research or epidemiology courses at the upper-undergraduate and graduate levels. It is also an indispensable reference for clinical research associates, clinical managers, clinical scientists, biostatisticians, pharmacologists, and any professional working in the field of clinical research who would like to better understand clinical research practices.

10545.46 RUR

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